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25-65)34(59)11-12-62(35
QL-IX-55 - CAS# 1223002-54-7 elin 25-65)34(59)11-12-62(35The functional target of QL IX 55 is the ATP binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL IX 55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL IX 55 is capable of
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