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also known as BMS-512148
9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-4
The inhibition of CDC20 with its inhibitor Apcin reduces the adhesion rate and proliferation ability to RL95-2 and HEC-1A cells
Harmston N
243(Pt B):1263-1273
PRX-08066 - CAS# 866206-54-4 411575 (isomer 3) also known as BMS-512148PRX 08066 is a a novel 5 hydroxytryptamine receptor 2B antagonist, reduces monocrotaline induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. In the 5 HT(2B) expressing SI NET cell line, KRJ I, PRX 08066 inhibited proliferation (IC(50) 4. 6 x 10( 9)M) and 5 HT secretion (6. 9 x 10( 9)M) and decreased ERK1 2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1],
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