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Brodowska K
The majority of the cell lines tested have IC50 values below 100 nM
and ameliorates impaired subcellular structure in rats treated with Aβ oligomers
is the first specific small molecule antagonist of cytoplasmic dynein
9 h) and Cmax (plasma
YM-201636 - CAS# 371942-69-7 size:2mg solid Brodowska KYM 201636, CAS No. 371942 69 7, is an inhibitor of retroviral budding and PIKfyve catalyzed PtdIns(3, 5)P2 synthesis, and can also halt glucose entry by insulin in adipocytes. YM 201636 almost completely inhibited basal and insulin activated 2 deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+ 4 nM for the net insulin response. Insulin induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those