OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S CAS Number: 1620401-82-2

CAS Number: 1620401-82-2

It inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro

CAS Number: 160096-59-3

and GMX-1778 are designed to assess efficacy and opportunistically used to assess retinal toxicity in mice

InChiKey: UCUHFWIFSHROPY-RWPZCVJISA-N

OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S CAS Number: 1620401-82-2OF 1, CAS No. 919973 83 4, is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2. 4 mM (ITC). It has general >100 fold selectivity against other bromodomains (39 fold selectivity over BRD4). OF 1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 M and also