I-BET151 (GSK1210151A) - BET Inhibitor. CAS# 1300031-49-5 426 Formula: C22H25N3O3

Name: I-BET151 (GSK1210151A) - BET Inhibitor. CAS# 1300031-49-5 426 Formula: C22H25N3O3
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Description

Formula: C22H25N3O3

I-BET151 (GSK1210151A) - BET Inhibitor. CAS# 1300031-49-5 426 Formula: C22H25N3O3I BET151 (GSK1210151A), CAS No. 1300031 49 5, is a novel and selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4 with IC50 of ~0. 5 M, 0. 25 M, and 0. 79 M respectively. It has profound effects on human and murine MLL fusion leukaemic cell lines, through the induction of early cell cycle arrest and apoptosis. The mode of action of I BET151 is, at least in part, due to the inhibition of transcription at

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