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CUDC-101 was IP or IV dosed to mice at 120 mg/kg once per day in the xenograft tumor model of Hep-G2
and in vivo in monkeys and humans
(241):77-83
PubMed PMID: 10822275
ATP secretion and thromboxane generation
Enzastaurin - CAS# 170364-57-5 0280 CUDC-101 was IP or IVEnzastaurin, CAS No. 170364 57 5, also known as DB 102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF) stimulated neo angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Product information CAS Number: